tag:blogger.com,1999:blog-4385530254120896026.post9147634213309343735..comments2023-03-21T12:46:14.067-04:00Comments on Midgaard: Where is the FDA?Don Monroehttp://www.blogger.com/profile/14057058447791467875noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-4385530254120896026.post-89649671530868983852009-09-08T04:23:10.485-04:002009-09-08T04:23:10.485-04:00OK, well I guess it's up to a court to decide....OK, well I guess it's up to a court to decide. I don't deny that the company worded things artfully.<br /><br />I do still think it's up to a physician to advise the patient and/or family appropriately. That's why they're given the authority to prescribe in the first place. If anything, I'd say the main complaint is with the physician.<br /><br />For that matter, a reputable pharmacist could give proper advice too.<br /><br />I certainly had enough experience with physicians doing a bad job in my mother's case, though not regarding Aricept.<br /><br />I'm sorry to hear your relative isn't doing well. I'd hope there is a power of attorney for health care that allows someone else to object to use of Aricept if that's his/her best judgment.Charles Daneyhttps://www.blogger.com/profile/04583013089740378307noreply@blogger.comtag:blogger.com,1999:blog-4385530254120896026.post-73749563741835107792009-09-06T22:26:21.553-04:002009-09-06T22:26:21.553-04:00Charles,
no argument on the alternatives.
But I ...Charles, <br />no argument on the alternatives.<br /><br />But I still think that "slows the progression of Alzheimer's symptoms" will be taken by <i>most</i> people to mean "slows the progression of Alzheimer's." For example, this second, incorrect interpretation was repeated quite unambiguously to me by a doctor involved in treating older patients, who should have known better. Of course that is how I came to study the data sheet.<br /><br />So we disagree on this. I assert that it's not worded so as to be "less than perfectly clear," it's worded deliberately to leave the wrong picture--and one that locks patients in. If they wanted to communicate accurately, or if the FDA required it of them, they could just say "relieves Alzheimer's symptoms." They didn't.<br /><br />I think this violates the law that "<a href="http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/ucm071964.htm" rel="nofollow">requires that advertising for prescription drugs be accurate and not misleading,</a>" although there are certainly worse offenders.<br /><br />Of course, part of the difference in our reaction may be that <i>my</i> relative who is suffering from dementia does not seem to have gotten any relief from even the symptoms, and is still going downhill fast. But the doctor continues to prescribe Aricept.Don Monroehttps://www.blogger.com/profile/14057058447791467875noreply@blogger.comtag:blogger.com,1999:blog-4385530254120896026.post-60262080126695247292009-09-06T17:48:51.632-04:002009-09-06T17:48:51.632-04:00Don,
You and I understand that Aricept is an acet...Don,<br /><br />You and I understand that Aricept is an acetylcholinesterase inhibitor, meaning it helps maintain levels of a neurotransmitter needed for memory. We also know that only slowing the actual death of neurons (from causes still unclear) could slow the disease.<br /><br />So it's as clear as anything could be that Aricept only relieves symptoms. A doctor who prescribes the drug should make these facts clear to the patient and family. That's their job, though not all might do it well.<br /><br />Indeed, for just about any type of therapy, cancer chemo for example, there are all kinds of qualifications a physician needs to explain about expectations for success. I don't see how this is any different.<br /><br />Regarding the ad, your critical quote speaks only of symptoms, so I'm not sure why you consider it to contradict the data sheet, although it's admittedly worded so as to be less than perfectly clear. That's the way just about all advertising is. <br /><br />The FDA does spend a lot of time policing claims made in drug ads. It's a judgment call how far to go. Unfortunately, no business can be trusted not to make its product seem better than it is.<br /><br />What's really too bad is that gov't can't come down harder on all those "alternative" herbs and supplements that aren't carefully tested to do anything useful at all. They aren't all especially cheap either.Charles Daneyhttps://www.blogger.com/profile/04583013089740378307noreply@blogger.comtag:blogger.com,1999:blog-4385530254120896026.post-2734730181912394052009-09-06T16:19:35.450-04:002009-09-06T16:19:35.450-04:00Thanks, Charles,
I'm glad to hear it helped ...Thanks, Charles,<br /><br />I'm glad to hear it helped for your mother. That is worth a lot, even though, as you recognize, we will never know what would have happened without it.<br /><br /> My post addressed a slightly different issue: does it slow the disease, or just improve the symptoms? The ad says one thing, the data sheet says the opposite. If it slows the disease, as the ad implies, you are virtually compelled to take it even it doesn't seem to work.Don Monroehttps://www.blogger.com/profile/14057058447791467875noreply@blogger.comtag:blogger.com,1999:blog-4385530254120896026.post-51970583662792412672009-09-06T15:41:22.834-04:002009-09-06T15:41:22.834-04:00My mother showed some improvement after starting A...My mother showed some improvement after starting Aricept. Of course, that's a subjective judgment, and only one data point. I recognize the limitations.<br /><br />However, during this period of improvement, it was possible for her to interact better with her family and friends. That's worth something, no?<br /><br />Aricept isn't especially expensive, either.<br /><br />In the end, the final decline was rapid. That's not such a bad thing, is it? It allowed us to have several years of reasonable time with her, instead of a slower, emotionally painful decline.Charles Daneyhttps://www.blogger.com/profile/04583013089740378307noreply@blogger.com